CID-2858522
货号：
14122-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 14122-1mg |
| 描述 | CID-2858522 is an 2-amino benzimidazole that inhibits activation of the NF-κB pathway induced by the PKC activator PMA with an IC50 value of 0.07 μM.1 It has been shown to inhibit IL-8 production induced by PKC activators in HEK293 cells (IC50 ≤ 0.1 μM), attenuate CD3/CD28 and PMA/ionomycin-induced production of IL-2 by Jurkat T cells (IC50 ≤ 5 μM), and prevent anti-IgM-stimulated proliferation of mouse B-lymphocytes (IC50 = ∼2 μM).1 CID-2858522 does not, however, inhibit the NF-κB pathway activated by TNF-α.1 |
| 别名 | ML-029; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Peddibhotla, S.,Shi, R.,Khan, P., et al. Inhibition of protein kinase C-driven nuclear factor-κB activation: Synthesis, structure-activity relationship, and pharmacological profiling of pathway specific benzimidazole probe molecules. Journal of Medicinal Chemistry 53(12), 4793-4797 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 465.6 |
| 分子式 | C28H39N3O3 |
| CAS号 | 758679-97-9 |
| 稳定性 | ≥ 2 years |
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