ZLN005
货号：
14121-5mg 基本售价：
406.0 元 规格：
5 mg
产品信息
概述| 货号 | 14121-5mg |
| 描述 | Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a tissue-specific and inducible transcriptional coactivator for several nuclear receptors and plays a key role in energy metabolism, hepatic gluconeogenesis, and cholesterol homoeostasis.1 ZLN005 is a small molecule that stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM.2 Chronic administration of 15 mg/kg/day ZLN005 to diabetic db/db mice increased PGC-1α and downstream gene transcription in skeletal muscle, increasing fat oxidation and improving glucose tolerance, pyruvate tolerance, and insulin sensitivity.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lin, J.,Handschin, C. and Spiegleman, B.M. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metabolism 1, 361-370 (2005).
2.Zhang, L.N.,Zhou, H.Y.,Fu, Y.Y., et al. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes 62(4), 1297-1307 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 250.3 |
| 分子式 | C17H18N2 |
| CAS号 | 49671-76-3 |
| 稳定性 | ≥ 2 years |
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