| 货号 | 13992-500ug |
| 描述 | 17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) (Item No. 16810) is a metabolically stable analog of PGF2α (Item No. 16010) with potent FP receptor agonist activity and well known intraocular pressure-reducing effects.1,2,3 17-phenyl trinor PF2α 1,15-lactone is the 1,15 lactone of 17-phenyl-trinor PGF2α. Selective F-series PG derivatives such as this compound have been developed for suitable pharmacologic activity and an improved side-effect profile over current glaucoma therapeutics.4,5 |
| 别名 | Bimatoprost free acid 1,15 lactone;17-phenyl trinor PGF2α1,15-lactone; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Balapure, A.K.,Rexroad, C.E., Jr.,Kawada, K., et al. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptor. Biochemical Pharmacology 38, 2375-2381 (1989). 2.Lake, S.,Gullberg, H.,Wahlqvist, J., et al. Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptor. FEBS Letters 355, 317-325 (1994). 3.Woodward, D.F.,Krauss, A.H.P.,Chen, J., et al. The pharmacology of Bimatoprost (Lumigan™). Survey of Ophthalmology 45, S337-S345 (2001). 4.Stjernschantz, J.W. From PGF2α-isopropyl ester to latanoprost: A review of the development of xalatan. The proper lecture. Investigative Ophthalmology & Visual Science 42(6), 1134-1145 (2001). 5.Maxey, K.M. and Stanton, M.L. Internal 1,15-lactones of fluprostenol and related prostaglandin F2α analogs and their use in the treatment of glaucoma and intraocular hypertension. 12/036,349, (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 370.5 |
| 分子式 | C23H30O4 |
| 稳定性 | ≥ 2 years |
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