5-Nitroso-8-quinolinol
货号：
13856-10mg 基本售价：
406.0 元 规格：
10 mg
产品信息
概述| 货号 | 13856-10mg |
| 描述 | 5-Nitroso-8-quinolinol is a chemically unique HDAC inhibitor that harbors a different Zn2+ chelation motif compared to SAHA.1,2 As an antitumor agent, 10 μM 5-nitroso-8-quinolinol can induce oxidative stress contributing to apoptosis and differentiation in MCF-7 breast cancer cells.1,2 Additionally, 5-nitroso-8-quinolinol inhibits T. gondii tachyzoite propagation in human fibroblasts with an EC50 value of 80 nM and inhibits P. falciparum growth in human red blood cells with an EC50 value of 1.3 μM.3 |
| 别名 | Hydron III;NSC 3852; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Martirosyan, A.R.,Rahim-Bata, R.,Freeman, A.B., et al. Differentiation-inducing quinolines as experimental breast cancer agents in the MCF-7 human breast cancer cell model. Biochemical Pharmacology 68(9), 1729-1738 (2004).
2.Martirosyan, A.,Leonard, S.,Shi, X., et al. Actions of a histone deacetylase inhibitor NSC3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor cells. Journal of Pharmacology and Experimental Therapeutics 317(2), 546-552 (2006).
3.Strobl, J.S.,Seibert, C.W.,Li, Y., et al. Inhibition of Toxoplasma gondii and Plasmodium falciparum infections in vitro by NSC3852, a redox active antiproliferative and tumor cell differentiation agent. Journal of Parasitology 95(1), 215-223 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 174.2 |
| 分子式 | C9H6N2O2 |
| CAS号 | 3565-26-2 |
| 稳定性 | ≥ 2 years |
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