S32826
货号：
13664-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 13664-1mg |
| 描述 | Autotaxin is a lysophospholipase D, cleaving lysophosphatidylcholine to produce choline and lysophosphatidic acid (LPA). S32826 is a potent and selective inhibitor of autotaxin, inhibiting recombinant autotaxin β with an IC50 of 8.8 nM.1 It shows similar effectiveness against the three known autotaxin isoforms (α, β, and γ). It has no effect on a variety of receptors and enzymes, with the exceptions of src (IC50 = 6 μM) and phosphatase 1B (IC50 = 15 μM).1 S32826 inhibits LPA release from adipocytes (IC50 = 90 nM) and reduces plasma autotaxin activity by 57% when used at 5 μM.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ferry, G.,Moulharat, N.,Pradère, J.P., et al. S32826, a nanomolar inhibitor of autotaxin: Discovery, synthesis and applications as a pharmacological tool. Journal of Pharmacology and Experimental Therapeutics 327, 809-819 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 397.5 |
| 分子式 | C21H36NO4P |
| CAS号 | 1096770-84-1 |
| 稳定性 | ≥ 2 years |
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