| 货号 | 13635-100ug |
| 描述 | Prostaglandin J2(PGJ2) is an analog of PGD2 that can inhibit both platelet aggregation and cell growth.1,2,3 However, it is not clear whether these effects are initiated by PGJ2 or a derivative. 13,14-dihydro-16,16-difluoro PGJ2 is an analog of PGJ2. While its biological activities have not been evaluated, it should be noted that the addition of two electron-withdrawing fluorine atoms has been used to stabilize prostanoids and significantly delay degradation in vivo.4 Importantly, 13,14-dihydro PGE1 has activity that is comparable to that of PGE1, suggesting that this analog of PGJ2 could be biologically active.5,6 |
| 别名 | 13,14-dihydro-16,16-difluoro PGJ2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bundy, G.L.,Morton, D.R.,Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. Journal of Medicinal Chemistry 26, 790-799 (1983). 2.Mahmud, I.,Smith, D.L.,Whyte, M.A., et al. On the identification and biological properties of prostaglandin J2. Prostaglandins, Leukotrienes and Medicine 16, 131-146 (1984). 3.Fukushima, M. Prostaglandin J2 - antitumor and anti-viral activities and the mechanisms involved. Eicosanoids 3, 189-199 (1990). 4.Hatano, Y.,Kohli, J.D.,Goldberg, L.I., et al. Vascular relaxing activity and stability studies of 10,10-difluoro-13,14-dehydroprostacyclin. Proceedings of the National Academy of Sciences of the United States of America 77(11), 6846-6850 (1980). 5.Änggård, E. The biological activities of three metabolites of prostaglandin E1. Acta Physiologica Scandinavica 66, 509-510 (1966). 6.Hamberg, M. and Samuelsson, B. On the metabolism of prostaglandins E1 and E2 in man. The Journal of Biological Chemisty 246, 6713-6721 (1971). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 372.5 |
| 分子式 | C20H30F2O4 |
| 稳定性 | ≥ 1 year |
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