IBMX
货号：
13347-100mg 基本售价：
406.0 元 规格：
100 mg
产品信息
概述| 货号 | 13347-100mg |
| 描述 | IBMX is a widely-used non-specific inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) (IC50 = 19, 50, 18, 13, 32, 7, and 50 μM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively). PDE8A, PDE8B, and PDE9 are insensitive to IBMX.1 By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors, typically antagonizing the suppressive effects of natural agonists.2 |
| 别名 | Isobutylmethylxanthine;1-Methyl-3-Isobutylxanthine;NSC 165960; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Fawcett, L.,Baxendale, R.,Stacey, P., et al. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. Proceedings of the National Academy of Sciences of the United States of America 97(7), 3702-3707 (2000).
2.Snyder, S.H.,Katims, J.J.,Annau, Z., et al. Adenosine receptors and behavioral actions of methylxanthines. Proc. Natl. Acad. Sci. USA 78(5), 3260-3264 (1981).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 222.3 |
| 分子式 | C10H14N4O2 |
| CAS号 | 28822-58-4 |
| 稳定性 | ≥ 2 years |
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