PD 158780
货号：
13329-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 13329-1mg |
| 描述 | PD 158780 is a pyridopyrimidine derivative that reversibly inhibits auto and transphosphorylation of all four members of the ErbB receptor tyrosine kinase superfamily: EGFR (IC50 = 8 µM), ErbB2 (IC50 = 49 nM), ErbB3, and ErbB4 (IC50 = 52 nM).1 It does not inhibit PDGF or FGF-mediated tyrosine phosphorylation.1 At 0.5 µM, PD 158780 has been shown to induce G1 cell cycle arrest in MCF10A breast cancer cells.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Fry, D.W.,Nelson, J.M.,Slintak, V., et al. Biochemical and antiproliferative properties of 4-[Ar(alk)ylamino]pyridopyrimidines, a new chemical class of potent and specific epidermal growth factor receptor tyrosine kinase inhibitor. Biochemical Pharmacology 54, 877-887 (1997).
2.Gonzales, A.J. and Fry, D.W. G1 cell cycle arrest due to the inhibition of erbB family receptor tyrosine kinases does not require the retinoblastoma protein. Experimental Cell Research 303, 56-67 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 330.2 |
| 分子式 | C14H12BrN5 |
| CAS号 | 171179-06-9 |
| 稳定性 | ≥ 2 years |
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