| 货号 | 13307-1mg |
| 描述 | Phosphatidylcholine-specific phospholipase C (PC-PLC) cleaves PC to generate diacylglycerol and phosphocholine. D609 is a xanthate that acts as a competitive inhibitor of PC-PLC (Ki = 6.4 µM).1 It does not affect bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA2, or phospholipase D.2 D609 also reduces sphingomyelin synthase activity, both in membrane preparations (IC50 = 100 µg/ml) and in cells.3 Like other xanthates, D609 has antioxidant, antiviral, and anti-tumor activities.2 In addition, it has anti-inflammatory actions, blocking the induction of nitric oxide synthase by LPS in phagocytes (IC50 = 20 µg/ml) and the expression of vascular cell adhesion molecule 1 by IL-1β in endothelial cells.4,5 |
| 别名 | Tricyclodecan-9-yl xanthogenate; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Amtmann, E. The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C. Drugs Under Experimental and Clinical Research 22, 287-294 (1996). 2.Adibhatla, R.M.,Hatcher, J.F. and Gusain, A. Tricyclodecan-9-yl-xanthogenate (D609) mechanism of actions: A mini-review of literature. Neurochemical Research 37(4), 671-679 (2012). 3.Luberto, C. and Hannun, Y.A. Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C? The Journal of Biological Chemisty 273(23), 14550-14559 (1998). 4.Tschaikowsky, K.,Meisner, M.,Schönhuber, F., et al. Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609). British Journal of Pharmacology 113(3), 664-668 (1994). 5.Cobb, R.R.,Felts, K.A.,Parry, G.C.N., et al. D609, a phosphatidylcholine-specific phospholipase C inhibitor, blocks interleukin-1β-induced vascular cell adhesion molecule 1 gene expression in human endothelial cells. Molecular Pharmacology 49, 998-1004 (1996). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 266.5 |
| 分子式 | C11H15OS2 • K |
| CAS号 | 83373-60-8 |
| 稳定性 | ≥ 2 years |
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