| 货号 | 13240-500ug |
| 描述 | Sphingosine-1-phosphate (S1P; Item No. 62570) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.1,2,3 It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8.1,2 VPC 23019 is an aryl amide-containing S1P analog that acts as a competitive antagonist at both S1P1 and S1P3 receptors (pKis = 7.86 and 5.93, respectively).4 It can inhibit S1P-induced migration of thyroid cancer cells, ovarian cancer cells, and neural stem cells.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Takuwa, Y.,Takuwa, N. and Sugimoto, N. The Edg family G protein-coupled receptors for lysophospholipids: Their signaling properties and biological activities. Journal of Biochemistry 131, 767-771 (2002). 2.Ishii, I.,Fukushima, N.,Ye, X., et al. Lysophospholipid receptors: Signaling and biology. Annual Reviews of Biochemistry 73, 321-354 (2004). 3.Kluk, M.J. and Hla, T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochimica et Biophysica Acta 1582, 72-80 (2002). 4.Davis, M.D.,Clemens, J.J.,Macdonald, T.L., et al. Sphingosine 1-phosphate analogs as receptor antagonists. The Journal of Biological Chemisty 280(11), 9833-9841 (2005). 5.Takabe, K.,Paugh, S.W.,Milstien, S., et al. "Inside-out" signaling of sphingosine-1-phosphate: Therapeutic targets. Pharmacological Reviews 60, 181-195 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 372.4 |
| 分子式 | C17H29N2O5P |
| CAS号 | 449173-19-7 |
| 稳定性 | ≥ 2 years |
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