VU0155069
货号：
13206-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 13206-1mg |
| 描述 | Phospholipase D (PLD) is an enzyme which cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD, PLD1 and PLD2, have been identified, with multiple splice variants of each. Although the two isoforms share structural and functional features, they are regulated differently and apparently subserve distinct roles. VU0155069 is a potent and selective inhibitor of phospholipase D (PLD)1, both in vitro(IC50 = 46 nM) and in cells (IC50 = 11 nM).1 It is also effective as a PLD2 inhibitor at higher concentrations (IC50 = 933 nM in vitro; 1,800 nM in cells).1 VU0155069 strongly inhibits the invasive migration of several breast cancer cell lines in transwell assays, suggesting that PLD might be a useful target in blocking tumor cell invasion.1 |
| 别名 | CAY10593; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Scott, S.A.,Selvy, P.E.,Buck, J.R., et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nature Chemical Biology 5(2), 108-117 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 463 |
| 分子式 | C26H27ClN4O2 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
