| 货号 | 13119-50mg |
| 描述 | Cisplatin is a platinum-containing compound that acts as an alkylating agent, interacting with DNA to form adducts which interfere with replication and transcription, culminating in apoptosis.1 It is used, alone or in combination therapy, in the treatment of several types of cancer, including testicular, ovarian, cervical, bladder, and lung cancers.1,2,3 Cisplatin also inhibits the RecA recombinase of M. tuberculosis(IC50 = 2 µM), blocking protein splicing and cell growth.4 |
| 别名 | CDDP;cis-Diamminedichloroplatinum;Cisplatinum;NSC 119875; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Schmitt, S.M.,Frezza, M. and Dou, Q.P. New applications of old metal-binding drugs in the treatment of human cancer. Front.Biosci.(Schol.Ed.) 4, 375-391 (2012). 2.Lokich, J. and Anderson, N. Carboplatin versus cisplatin in solid tumors: An analysis of the literature. Annals of Oncology 9(1), 13-21 (1998). 3.Perabo, F.G.E. and Müller, S.C. New agents for treatment of advanced transitional cell carcinoma. Annals of Oncology 18, 835-843 (2007). 4.Zhang, L.,Zheng, Y.,Callahan, B., et al. Cisplatin inhibits protein splicing, suggesting inteins as therapeutic targets in mycobacteria. The Journal of Biological Chemisty 286(2), 1277-1282 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 300.1 |
| 分子式 | Cl2H6N2Pt |
| CAS号 | 15663-27-1 |
| 稳定性 | ≥ 2 years |
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