Cidofovir
货号：
13113-25mg 基本售价：
406.0 元 规格：
25 mg
产品信息
概述| 货号 | 13113-25mg |
| 描述 | Cidofovir is an acyclic nucleoside phosphonate that is active against herpesvirus (including cytomegalovirus (CMV)), polyomavirus, papillomavirus, adenovirus, and poxvirus infections. In vitro, cidofovir is converted to cidofovir diphosphate which incorporates into viral DNA, selectively inhibiting CMV replication and CMV DNA synthesis with IC50 values of 0.1 μM.1 Cidofovir has significantly long-lasting antiviral action because of the long half-life of its metabolites whose cellular uptake is slow due to the presence of the negatively charged phosphonate group.2 The antiviral efficacy of cidofovir has been demonstrated in numerous experimental animal model infections that mirror all major DNA virus infections in humans.3 It has also demonstrated remarkable activity as an antitumor agent in a variety of animal models of tumor growth.3 |
| 别名 | GS-0504;HPMPC;Vistide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Snoeck, R.,Sakuma, T.,De Clercq, E., et al. (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication. Antimicrobial Agents and Chemotherapy 32(12), 1839-1844 (1988).
2.Connelly, M.C.,Robbins, B.L. and Fridland, A. Mechanism of uptake of the phosphonate analog (S)-1-(3-hydroxy-2-phosphonylmethoxy-propyl)cytosine (HPMPC) in vero cells. Biochemical Pharmacology 46(6), 1053-1057 (1993).
3.De Clercq, E. Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections. Clin.Microbiol.Rev. 16(4), 569-596 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 279.2 |
| 分子式 | C8H14N3O6P |
| CAS号 | 113852-37-2 |
| 稳定性 | ≥ 2 years |
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