Mubritinib
货号：
12096-5mg 基本售价：
406.0 元 规格：
5 mg
产品信息
概述| 货号 | 12096-5mg |
| 描述 | Mubritinib is a selective inhibitor of the human epidermal growth factor receptor 2 (HER2), inhibiting HER2 phosphorylation with an IC50 value of 6 nM.1 It is without effect on EGFR, FGFR, PDGFR, JAK1, Src, and Blk (IC50 > 25 μM).1 Mubritinib inhibits the proliferation of breast, bladder, kidney, and prostate cancer cells in vitroandin vivo.1,2 |
| 别名 | TAK-165; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Nagasawa, J.,Mizokami, A.,Koshida, K., et al. Novel HER2 selective tyrosine kinase inhibitor, TAK-165, inhibits bladder, kidney and androgen-independent prostate cancer in vitro and in vivo. Int.J.Urol. 13, 587-592 (2006).
2.Sridhar, S.S.,Seymour, L., and Shepherd, F.A. Inhibitors of epidermal-growth-factor receptors: A review of clinical research with a focus on non-small-cell lung cancer. Lancet Oncol. 4(7), 397-406 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 468.5 |
| 分子式 | C25H23F3N4O2 |
| CAS号 | 366017-09-6 |
| 稳定性 | ≥ 2 years |
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