| 货号 | 12077-1mg |
| 描述 | Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity.1,2 1-hydroxy Vitamin D2 is a synthetic prodrug of the active 1,25-dihydroxy vitamin D2 (Item No. 11174), as well as of other active metabolites.3 It is used to suppress the synthesis and secretion of parathyroid hormone in secondary hyperparathyroidism, an action which requires vitamin D receptor.4,5,6 1-hydroxy Vitamin D2 is effective in stimulating bone growth and, in combination therapy with angiotensin receptor blockers, ameliorates albuminuria and glomerulosclerosis associated with diabetic nephropathy.7,8 It also inhibits the growth of certain blastomas and prostate cancer cells.9,10 |
| 别名 | Doxercalciferol;Hectorol;1-Hydroxyergocalciferol;TSA 840; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Holick, M.F. Vitamin D deficiency. New England Journal of Medicine 357(3), 266-281 (2007). 2.Peterlik, M.,Boonen, S.,Cross, H.S., et al. Vitamin D and calcium insufficiency-related chronic diseases: An emerging world-wide public health problem. Int.J.Environ.Res.Public Health 6, 2585-2607 (2009). 3.Upton, R.A.,Knutson, J.C.,Bishop, C.W., et al. Pharmacokinetics of doxercalciferol, a new vitamin D analogue that lowers parathyroid hormone. Nephrology Dialysis Transplantation 18, 750-758 (2003). 4.Frazao, J.M.,Chesney, R.W.,Coburn, J.W., et al. Intermittent oral 1α-hydroxyvitamin D2 is effective and safe for the suppression of secondary hyperparathyroidism in haemodialysis patients. Nephrology Dialysis Transplantation 13, 68-72 (1998). 5.Brown, A.J.,Dusso, A.S., and Slatopolsky, E. Vitamin D analogues for secondary hyperparathyroidism. Nephrology Dialysis Transplantation 17, 10-19 (2002). 6.Ritter, C.S., and Brown, A.J. Direct suppression of Pth gene expression by the vitamin D prohormones doxercalciferol and calcidiol requires the vitamin D receptor. Journal of Molecular Endocrinology 46(2), 63-66 (2011). 7.Nguyen-Yamamoto, L.,Bolivar, I.,Strugnell, S.A., et al. Comparison of active vitamin D compounds and a calcimimetic in mineral homeostasis. Journal of the American Society of Nephrology 21, 1713-1723 (2010). 8.Zhang, Y.,Deb, D.K.,Kong, J., et al. Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: Strong synergism with AT1 receptor antagonist. American Journal of Physiology.Renal Physiology 297, F791-F801 (2009). 9.van Ginkel, P.R.,Yang, W.,Marcet, M.M., et al. 1α-Hydroxyvitamin D2 inhibits growth of human neuroblastoma. Journal of Neuro-Oncology 85, 255-262 (2007). 10.Attia, S.,Eickhoff, J.,Wilding, G., et al. Randomized, double-blinded phase II evaluation of docetaxel with or without doxercalciferol in patients with metastatic, androgen-independent prostate cancer. Clinical Cancer Research 14(8), 2437-2443 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 412.7 |
| 分子式 | C28H44O2 |
| CAS号 | 54573-75-0 |
| 稳定性 | ≥ 2 years |
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