SR 2211
货号：
11972-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 11972-1mg |
| 描述 | Retinoic acid receptor-related nuclear receptor γ (RORγ) plays a central role in T cell differentiation, particularly in the differentiation of pro-inflammatory TH17 cells, which are implicated in autoimmune diseases like multiple sclerosis and rheumatoid arthritis.1,2 SR 2211 selectively binds RORγ (Ki = 105 nM), acting as an inverse agonist of constitutive in vitro RORγ activity (IC50 = 320 nM).3 It has minimal effects on RORα, LXRα, and FXR activities. SR 2211 significantly inhibits gene expression of IL-17 and IL-23 receptor in activated EL-4 mouse T lymphocytes when given at 5 μM.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ivanov, I.I.,McKenzie, B.S.,Zhou, L., et al. The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126, 1121-1133 (2006).
2.Solt, L.A.,Kumar, N.,Nuhant, P., et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nat.Lett. 472(7344), 491-494 (2011).
3.Kumar, N.,Lyda, B.,Chang, M.R., et al. Identification of SR2211: A potent synthetic RORγ-selective modulator. ACS Chemical Biology 7, 672-677 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 527.5 |
| 分子式 | C26H24F7N3O |
| CAS号 | 1359164-11-6 |
| 稳定性 | ≥ 2 years |
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