| 货号 | 11841-1mg |
| 描述 | 8-Gingerol is a natural chemical found in the rhizomes of ginger (Z. officinale). It contains the same aromatic region and polar link but has a longer hydrophobic tail than the more abundant 6-gingerol (Item No. 11707). Like 6-gingerol, 8-gingerol activates the transient receptor potential vanilloid receptor 1 (TRPV1; EC50 = 5.0 µM), inhibits COX-2, and inhibits the growth of H. pyloriin vitro.1,2 8-Gingerol also augments wound healing, suppresses IL-2-induced proliferation of T lymphocytes, and potentiates β-agonist-induced relaxation of airway smooth muscle.3,4,5 Oral 8-gingerol is expected to be readily absorbed and rapidly metabolized by glucuronidation and sulfation, with minimal to modest effects on cytochrome P450 isoforms.6,7 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Dedov, V.N.,Tran, V.H.,Duke, C.C., et al. Gingerols: a novel class of vanilloid receptor (VR1) agonists. Br. J. Pharmacol. 137(6), 793-798 (2002). 2.Chrubasik, S.,Pittler, M.H., and Roufogalis, B.D. Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles. Phytomedicine 12(9), 684-701 (2005). 3.Bakht, M.A.,Alajmi, M.F.,Alam, P., et al. Theoretical and experimental study on lipophilicity and wound healing activity of ginger compounds. Asian Pac. J. Trop. Med. 4(4), 329-333 (2014). 4.Bernard, M.,Furlong, S.J.,Power Coombs, M.R., et al. Differential inhibition of T lymphocyte proliferation and cytokine synthesis by [6]-Gingerol, [8]-Gingerol, and [10]-Gingerol. Phytother. Res. 29(11), 1707-1713 (2015). 5.Townsend, E.A.,Zhang, Y.,Xu, C., et al. Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins. Am. J. Respir. Cell Mol. Biol. 50(1), 115-124 (2014). 6.Mukkavilli, R.,Gundala, S.R.,Yang, C., et al. Modulation of cytochrome P450 metabolism and transport across intestinal epithelial barrier by ginger biophenolics. PLoS One 9(9), e108386 (2014). 7.Qiu, J.-X.,Zhou, Z.-W.,He, Z.-X., et al. Estimation of the binding modes with important human cytochrome P450 enzymes, drug interaction potential, pharmacokinetics, and hepatotoxicity of ginger components using molecular docking, computational, and pharmacokinetic modeling studies. Drug. Des. Devel. Ther. 9, 841-866 (2015). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 322.4 |
| 分子式 | C19H30O4 |
| CAS号 | 23513-08-8 |
| 稳定性 | ≥ 2 years |
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