| 货号 | 11764-5mg |
| 描述 | Vincristine is an antimitotic vinca alkaloid, isolated from the plant V. rosea. It irreversibly blocks mitosis by binding to tubulin (Ki = 85 nM) and inhibiting tubulin polymerization.1,2 Vincristine is exported from cells via the ATP-binding cassette transporter P-glycoprotein, but not by multidrug resistance-associated protein.3 Its effectiveness in blocking the proliferation of cancer cells is affected by overexpression of P-glycoprotein.4 |
| 别名 | Kyocristine;Lilly 37231;Leurocristine;Novopharm;NSC 67574;Oncovin;VCR; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jordan, M.A.,Himes, R.H., and Wilson, L. Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Research 45(6), 2741-2747 (1985). 2.Towle, M.J.,Salvato, K.A.,Wels, B.F., et al. Eribulin induces irreversible mitotic blockade: Implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Research 71(2), 496-505 (2011). 3.van Tellingen, O.,Buckle, T.,Jonker, J.W., et al. P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo. British Journal of Cancer 89(9), 1776-1782 (2003). 4.Chan, H.S.L.,Haddad, G.,Thorner, P.S., et al. P-glycoprotein expression as a predictor of the outcome of therapy for neuroblastoma. New England Journal of Medicine 325(23), 1608-1614 (1991). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 923 |
| 分子式 | C46H56N4O10 • H2SO4 |
| CAS号 | 2068-78-2 |
| 稳定性 | ≥ 2 years |
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