| 货号 | 11672-1mg |
| 描述 | 3-acetyl-11-keto-β-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata(frankincense).1 It selectively inhibits 5-lipoxygenase (IC50 = 1.5 µM) in an enzyme-directed, nonredox, and noncompetitive manner.2 3-acetyl-11-keto-β-Boswellic acid and other members of the boswellic acid family have been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.3,4,5,6 |
| 别名 | 3-O-acetyl-11-keto-β-Boswellic acid;AKBA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ammon, H.P.,Safayhi, H.,Mack, T., et al. Mechanism of antiinflammatory actions of curcumine and boswellic acids. Journal of Ethnopharmacology 38(2-3), 113-119 (1993). 2.Safayhi, H.,Mack, T.,Sabieraj, J., et al. Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. Journal of Pharmacology and Experimental Therapeutics 261, 1143-1146 (1992). 3.Zhao, W.,Entschladen, F.,Liu, H., et al. Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells. Cancer Detection and Prevention 27(1), 67-75 (2003). 4.Xia, L.,Chen, D.,Han, R., et al. Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells. Molecular Cancer Therapeutics 4(3), 381-388 (2005). 5.Mostafa, D.M.,Ammar, N.M.,Basha, M., et al. Transdermal microemulsions of Boswellia carterii Bird: Formulation, characterization and in vivo evaluation of anti-inflammatory activity. Drug Deliv. 22(6), 748-756 (2015). 6.Wang, Q.,Pan, X.,Wong, H.H., et al. Oral and topical boswellic acid attenuates mouse osteoarthritis. Osteoarthritis Cartilage 22(1), 128-132 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 512.7 |
| 分子式 | C32H48O5 |
| CAS号 | 67416-61-9 |
| 稳定性 | ≥ 2 years |
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