MI-2 (hydrochloride)
货号：
11620-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 11620-1mg |
| 描述 | Menin, a product of the multiple endocrine neoplasia gene, is an essential component of histone methyltransferase complexes involving the mixed lineage leukemia (MLL) gene product.1,2 Also, the leukemogenic activity of MLL fusion proteins depends on their direct interaction with menin.3 MI-2 potently binds menin, blocks the menin-MLL fusion protein interaction (IC50 = 0.45 μM), and induces apoptosis in cells expressing MLL fusion proteins.3 Its actions can be compared with those of MI-nc (Item No. 11621), a weak inhibitor of the menin MLL interaction (IC50 = 193 μM).3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chandrasekharappa, S.C.,Guru, S.C.,Manickam, P., et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 276, 404-407 (1997).
2.Guccione, E.,Bassi, C.,Casadio, F., et al. Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive. Nature 449, 933-937 (2007).
3.Grembecka, J.,He, S.,Shi, A., et al. Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nature Chemical Biology 8, 277-284 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 448.5 |
| 分子式 | C18H25N5S2 • 2HCl |
| 稳定性 | ≥ 2 years |
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