| 货号 | 11615-10mg |
| 描述 | Angiotensin II is a peptide hormone which regulates blood pressure and fluid balance, contributing to hypertension, atherosclerosis, left ventricular hypertrophy, myocardial infarction, and heart failure.1 Telmisartan is a nonpeptide angiotensin II receptor antagonist which selectively and insurmountably inhibits the angiotensin II AT1 receptor subtype (Ki = 3.7 nM).2 It also acts as a partial agonist of PPARγ, activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (EC50 = 4.5 μM).3 Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis.4,5,6 |
| 别名 | BIBR 277;Micardis;Pritor; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Frampton, J.E. Telmisartan: A review of its use in cardiovascular disease prevention. Drugs 71, 651-677 (2011). 2.Wienen, W.,Hauel, N.,Van Meel, J.C.A., et al. Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277. Br. J. Pharmacol. 110, 245-252 (1993). 3.Benson, S.C.,Pershadsingh, H.A.,Ho, C.I., et al. Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARγ-modulating activity. Hypertension 43(5), 993-1002 (2004). 4.McClellan, K.J., and Markham, A. Telmisartan. Drugs 56(6), 1039-1044 (1998). 5.Jugdutt, B.I. Clinical effectiveness of telmisartan alone or in combination therapy for controlling blood pressure and vascular risk in the elderly. Clin. Interv. Aging 5, 403-416 (2010). 6.Schmieder, R.E.,Bakris, G., and Weir, M.R. Telmisartan in incipient and overt diabetic renal disease. J.Nephrol. 24(3), 263-273 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 514.6 |
| 分子式 | C33H30N4O2 |
| CAS号 | 144701-48-4 |
| 稳定性 | ≥ 2 years |
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