Kynurenine
货号：
11305-50mg 基本售价：
406.0 元 规格：
50 mg
产品信息
概述| 货号 | 11305-50mg |
| 描述 | Kynurenine is a product of constitutive tryptophan catabolism via tryptophan-2,3-dioxygenase in the liver and human gliomas that is associated with the suppression of antitumor immune responses. At 100 μM, kynurenine inhibits allogeneic T-cell proliferation and increases malignant U87 glioma cell invasion into a collagen matrix.1 Kynurenine activates the aryl hydrocarbon receptor (AhR) target gene CYP1A1 with an EC50 value of 12.3 μM and binds to AhR with an apparent Kd value of ~4 μM.1 Kynurenine is ultimately metabolized to quinolinic acid, a potent neurotoxin that acts as an NMDA agonist and has been described to be involved in neurodegenerative processes in the brain.2 |
| 别名 | 3-anthraniloyl-Alanine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Opitz, C.A.,Litzenburger, U.M.,Sahm, F., et al. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature 478, 197-203 (2011).
2.Stone, T.W.,Forrest, C.M., and Darlington, L.G. Kynurenine pathway inhibition as a therapeutic strategy for neuroprotection. FEBS Journal 279 (8), 1386-1397 (2012).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 208.2 |
| 分子式 | C10H12N2O3 |
| CAS号 | 2922-83-0 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
