SGI-1027
货号：
11165-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 11165-1mg |
| 描述 | SGI-1027 is an inhibitor of the DNA methyltransferases DNMT1, DNMT3A, and DNMT3B (IC50s = 12.5, 8, and 7.5 μM, respectively, with Poly(dI-dC) as the substrate).1 It has been shown to cause the degradation of DNMT1 and to reactivate silenced tumor suppressor genes by reducing CpG island hypermethylation.1 |
| 别名 | DNA Methyltransferase Inhibitor II; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Datta, J.,Ghoshal, K.,Denny, W.A., et al. A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degredation. Cancer Research 69(10), 4277-4285 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 461.5 |
| 分子式 | C27H23N7O |
| CAS号 | 1020149-73-8 |
| 稳定性 | ≥ 2 years |
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