Ki16425
货号：
10012659-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 10012659-1mg |
| 描述 | Lysophosphatidic acid (LPA) is a bioactive lipid mediator that signals through five distinct G protein-coupled receptors (LPA1-5).1 Ki16425 is a LPA receptor antagonist with selectivity for LPA1 and LPA3. It exhibits Ki values of 0.34, 6.5, and 0.93 µM for the human LPA1, LPA2, and LPA3 receptors, respectively, as determined by measuring inositol phosphate production in RH7777-transfected cells.2 Ki1642, at 10 µM, significantly blocks the response of a variety of cancer cell lines to LPA-induced cell migration.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Choi, J.W.,Lee, C.W., and Chun, J. Biological roles of lysophospholipid receptors revealed by genetic null mice: An update. Biochimica et Biophysica Acta 1781, 531-539 (2008).
2.Ohta, H.,Sato, K.,Murata, N., et al. Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors. Molecular Pharmacology 64(4), 994-1005 (2003).
3.Yamada, T.,Sato, K.,Komachi, M., et al. Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA. The Journal of Biological Chemisty 279(8), 6595-6605 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 475 |
| 分子式 | C23H23ClN2O5S |
| CAS号 | 355025-24-0 |
| 稳定性 | ≥ 1 year |
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