A-803467
货号：
10012588-5mg 基本售价：
406.0 元 规格：
5 mg
产品信息
概述| 货号 | 10012588-5mg |
| 描述 | Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel with high activation threshold and slow inactivating kinetics that is highly expressed in small-diameter sensory neurons and has been implicated in signaling various types of pain. A-803467 is a sodium channel blocker with high-affinity and selectivity for inhibiting human Nav1.8 sodium channels (IC50 = 8 nM when stimulated at half-maximal inactivation and IC50 = 79 nM at a resting state). 1 This compound is unusual in that it blocks hNav1.8 at negative resting membrane potentials (many small molecule sodium channel blockers show a reduced affinity for the resting state) and does not demonstrate significant frequency-dependent block during a 10 Hz pulse train.2 A-803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jarvis, M.F.,Honore, P.,Shieh, C.C., et al. A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proceedings of the National Academy of Sciences of the United States of America 104(20), 8520-8525 (2007).
2.Krafte, D.S.,Chapman, M.,Marron, B., et al. Block of NAv1.8 by small molecules. Channels 1(3), 152-153 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 357.8 |
| 分子式 | C19H16ClNO4 |
| CAS号 | 944261-79-4 |
| 稳定性 | ≥ 2 years |
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