TWS119
货号：
10011251-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 10011251-1mg |
| 描述 | Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by a number of extracellular stimuli such as insulin, growth factors, cell specification factors, and cell adhesion. Its activity regulates many cell functions including cell division, apoptosis, and inflammation. TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.1 At 400 nM, TWS119 induces neurogenesis in mouse embryonic stem cells making it a useful tool to regulate stem cell self-renewal and differentiation.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ding, S.,Wu, T.Y.H.,Brinker, A., et al. Synthetic small molecules that control stem cell fate. Proceedings of the National Academy of Sciences of the United States of America 100(13), 7632-7637 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 318.3 |
| 分子式 | C18H14N4O2 |
| CAS号 | 601514-19-6 |
| 稳定性 | ≥ 2 years |
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