GW 5074
货号：
10010368-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 10010368-1mg |
| 描述 | Raf-1 is a proto-oncogene serine/threonine protein kinase that signals from Ras to the MAPK/ERK signaling pathway.1,2 This pathway mediates basic cellular functions, including proliferation, differentiation, and survival.1 GW 5074 is a potent, selective, and cell-permeable inhibitor of Raf-1 (IC50 = 9 nM).3 It blocks phosphorylation of ERK1/2 by 90% in cells stimulated with epidermal growth factor when given at 5 µM.3 GW 5074 shows more than 100-fold selectivity for Raf-1 versus several related kinases.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Dhillon, A.S., and Kolch, W. Untying the regulation of the Raf-1 kinase. Archives of Biochemistry and Biophysics 404, 3-9 (2002).
2.Kunnimalaiyaan, M., and Chen, H. The Raf-1 pathway: a molecular target for treatment of select neuroendocrine tumors? Anti-Cancer Drugs 17, 139-142 (2006).
3.Lackey, K.,Cory, M.,David, R., et al. The discovery of potent cRaf1 kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 10(3), 223-226 (2000).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 520.9 |
| 分子式 | C15H8Br2INO2 |
| CAS号 | 220904-83-6 |
| 稳定性 | ≥ 2 years |
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