CAY10505
货号：
10009078-5mg 基本售价：
406.0 元 规格：
5 mg
产品信息
概述| 货号 | 10009078-5mg |
| 描述 | Phosphoinositide 3-kinase γ (PI3Kγ), expressed primarily in hematopoietic cells, plays several important roles in immunity. CAY10505 is a potent inhibitor of PI3K, selectively inhibiting the γ isoform (IC50 = 30 nM) better than the α, β, and δ isoforms (IC50 = 0.94, 20, and 20 μM, respectively).1 Tested against a panel of 80 other kinases, CAY10505 significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). It also inhibits the phosphorylation of the PI3K substrate PKB/Akt in mouse macrophages (IC50 = 228 nM).1 Oral administration of CAY10505 reduces neutrophil recruitment in mice to an extent that is comparable to that observed in PI3Kγ-deficient mice.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pomel, V.,Klicic, J.,Covini, D., et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase γ. Journal of Medicinal Chemistry 49, 3857-3871 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 289.3 |
| 分子式 | C14H8FNO3S |
| CAS号 | 328960-84-5 |
| 稳定性 | ≥ 2 years |
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