| 货号 | 10008187-1mg |
| 描述 | Dimethylcurcumin is a selective enhancer of androgen receptor (AR) degradation. By disrupting the interaction between AR and its coregulators, dimethylcurcumin directs the degradation of AR and reduces signaling through this receptor both in cultured cells and in animals.1,2,3 In this way, dimethylcurcumin suppresses the growth of hepatocellular carcinoma (HCC) cells both in culture and in mice.2 Dimethylcurcumin can be used to elucidate the consequences of signaling through AR in various cell types.1,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lai, J.-J.,Lai, K.-P.,Chuang, K.-H., et al. Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-α expression. J. Clin. Invest. 119(12), 3739-3751 (2009). 2.Ma, W.-L.,Hsu, C.-L.,Wu, M.-H., et al. Androgen receptor is a new potential therapeutic target for the treatment of hepatocellular carcinoma. Gastroenterology 135(3), 947-955 (2008). 3.Yang, Z.,Chang, Y.-J.,Yu, I.-C., et al. ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor. Nat. Med. 13(3), 348-353 (2007). 4.Wen, S.,Niu, Y.,Lee, S.O., et al. Targeting fatty acid synthase with ASC-J9 suppresses proliferation and invasion of prostate cancer cells. Mol. Carcinog. 55(12), 2278-2290 (2016). 5.Xu, J.,Lin, H.,Li, G., et al. Sorafenib with ASC-J9® synergistically suppresses the HCC progression via altering the pSTAT3-CCL2/Bcl2 signals. Int. J. Cancer 140(3), 705-717 (2017). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 396.4 |
| 分子式 | C23H24O6 |
| CAS号 | 52328-98-0 |
| 稳定性 | ≥ 2 years |
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