Perifosine
货号：
10008112-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 10008112-1mg |
| 描述 | Alkylphospholipids are a class of antineoplastic compounds that display potent antiproliferative activity in several in vitroandin vivo human tumor models. Perifosine is an alkylphospholipid that induces apoptotic cell death in a variety of tumor cell lines.1 Apoptosis is induced in a time- and dose-dependent manner in U937 and Jurkat T human leukemia cell lines but not in normal vascular endothelial cells. Perifosine causes inhibition of PC-3 prostate carcinoma cell growth (growth inhibition (GI50) = 5 µM at 24 h) and is associated with rapidly decreased Akt activation.2 In addition, perifosine induces p21WAF1 expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ruiter, G.A.,Zerp, S.F.,Bartelink, H., et al. Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis. Cancer Research 59, 2457-2463 (1999).
2.Kondapaka, S.B.,Singh, S.S.,Dasmahapatra, G.P., et al. Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation. Molecular Cancer Therapeutics 2, 1093-1103 (2003).
3.Patel, V.,Lahusen, T.,Sy, T., et al. Perifosine, a novel alkylphospholipid, induces p21WAF1 expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest. Cancer Research 62, 1401-1409 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 462.7 |
| 分子式 | C25H53NO4P |
| CAS号 | 157716-52-4 |
| 稳定性 | ≥ 2 years |
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