| 货号 | 16982-1mg |
| 描述 | Perhexiline is a carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor that was originally developed as an anti-anginal drug in the 1970s.1,2,3 It inhibits rat heart and liver CPT1 (IC50 = 77 and 148 µM, respectively) and rat heart CPT2 (IC50 = 79 µM).1,2 Inhibition of CPT reduces uptake of long-chain fatty acids into the mitochondria, thereby shifting cellular metabolism from β-oxidation to glycolysis. Perhexilin inhibits mTORC1 signaling at 10 µM and induces autophagy ~7-fold at a concentration of 10 µM in MCF-7 cells.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kennedy, J.A.,Unger, S.A., and Horowitz, J.D. Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone. Biochemical Pharmacology 52(2), 273-280 (1996). 2.Kennedy, J.A.,Kiosoglous, A.J.,Murphy, G.A., et al. Effect of perhexiline and oxfenicine on myocardial function and metabolism during low-flow ischemia/reperfusion in the isolated rat heart. Journal of Cardiovascular Pharmacology 36(6), 794-801 (2000). 3.Ashrafian, H.,Horowitz, J.D., and Frenneaux, M.P. Perhexiline. Cardiovascular Drug Reviews 25(1), 76-97 (2007). 4.Balgi, A.D.,Fonseca, B.D.,Donohue, E., et al. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 4(9), 1-15 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 393.6 |
| 分子式 | C19H35N • C4H4O4 |
| CAS号 | 6724-53-4 |
| 稳定性 | ≥ 2 years |
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