| 货号 | 13857-5mg |
| 描述 | Nocodazole reversibly binds tubulin and alters tubulin-associated GTP hydrolysis as well as microtubule dynamics.1,2 While nocodazole is used to study many aspects on microtubule function, it is most commonly used to synchronize cell cycling in culture.3,4 Typically, nanomolar concentrations of nocodazole reduce both microtubule elongation and shortening velocities, resulting in arrest of cycling in a G2/M phase.5,3 Nocodazole is also used to induce the formation of Golgi ministacks in eukaryotic cells.2 |
| 别名 | NSC 238159;Oncodazole;R 17934; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mejillano, M.R.,Shivanna, B.D. and Himes, R.H. Studies on the nocodazole-induced GTPase activity of tubulin. Archives of Biochemistry and Biophysics 336(1), 130-138 (1996). 2.Thyberg, J. and Moskalewski, S. Role of microtubules in the organization of the Golgi complex. Experimental Cell Research 246, 263-279 (1999). 3.Lee, J.Y.,Leonhardt, L.G. and Obeid, L.M. Cell-cycle-dependent changes in ceramide levels preceding retinoblastoma protein dephosphorylation in G2/M. Biochemistry Journal 334, 457-461 (1998). 4.Blajeski, A.L.,Phan, V.A.,Kottke, T.J., et al. G1 and G2 cell-cycle arrest following microtubule depolymerization in human breast cancer cells. Journal of Clinical Investigation 110(1), 91-99 (2002). 5.Vasquez, R.J.,Howell, B.,Yvon, A.M.C., et al. Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro. Molecular Biology of the Cell 8(6), 973-985 (1997). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 301.3 |
| 分子式 | C14H11N3O3S |
| CAS号 | 31430-18-9 |
| 稳定性 | ≥ 2 years |
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