| 货号 | 11345-1mg |
| 描述 | Paxilline is an indole diterpene from fungi which potently and reversibly inhibits large conductance Ca2+-activated K+ (BKCa) channels, as shown in patch clamp (Ki = 1.9 nM) and whole smooth muscle cell studies (Ki = 35.7 nM).1,2 It also enhances the binding of charybdotoxin, a peptidyl neurotoxin, to BKCa channels.3 Paxilline is currently used to evaluate the role of BKCa channels in various cell processes and responses.4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sanchez, M. and McManus, O.B. Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Neuropharmacology 35(7), 963-968 (1996). 2.Li, G. and Cheung, D.W. Effects of paxilline on K+ channels in rat mesenteric arterial cells. European Journal of Pharmacology 372, 103-107 (1999). 3.Knaus, H.G.,McManus, O.B.,Lee, S.H., et al. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry 33(19), 5819-5828 (1994). 4.Jackson-Weaver, O.,Paredes, D.A.,Gonzalez Bosc, L.V., et al. Intermittent hypoxia in rats increases myogenic tone through loss of hydrogen sulfide activation of large-conductance Ca2+-activated potassium channels. Circulation Research 108(12), 1439-1447 (2011). 5.Tajima, N.,Itokazu, Y.,Korpi, E.R., et al. Activity of BKCa channel is modulated by membrane cholesterol content and association with Na+/K+-ATPase in human melanoma IGR39 cells. The Journal of Biological Chemisty 286(7), 5624-5638 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 435.6 |
| 分子式 | C27H33NO4 |
| CAS号 | 57186-25-1 |
| 稳定性 | ≥ 2 years |
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