Arachidonoyl Cyclopropylamide
货号：
91053-5mg 基本售价：
392.0 元 规格：
5 mg
产品信息
概述| 货号 | 91053-5mg |
| 描述 | Arachidonoyl ethanolamide (AEA) was the first endogenous cannabinoid to be isolated and characterized as an agonist acting on the same receptors (CB1 and CB2) as tetrahydrocannabinols (THC).1,2 Arachidonoyl cyclopropamide (ACPA) is a potent, stable, and selective agonist analog of AEA. ACPA has an Ki value of 2.2 nM at the isolated rat CB1 receptor, and is 325 times more potent at the CB1 receptor compared with the CB2receptor.3 In whole animal experiments, ACPA induces hypothermia in mice with the same efficacy as AEA, in spite of its much higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACPA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.3 |
| 别名 | ACPA; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Devane, W.A.,Hanus, L.,Breuer, A., et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258, 1946-1949 (1992).
2.Felder, C.C.,Briley, E.M.,Axelrod, J., et al. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. Proceedings of the National Academy of Sciences of the United States of America 90, 7656-7660 (1993).
3.Hillard, C.J.,Manna, S.,Greenberg, M.J., et al. Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1). Journal of Pharmacology and Experimental Therapeutics 289, 1427-1433 (1999).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 343.6 |
| 分子式 | C23H37NO |
| CAS号 | 229021-64-1 |
| 稳定性 | ≥ 1 year |
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