| 货号 | 20846-500ug |
| 描述 | N-methyl Protoporphyrin IX is a transition state analog that potently inhibits protoporphyrin IX ferrochelatase (Ki = 10 nM), blocking the terminal step of the heme biosynthetic pathway.1,2 It is used to study the effect of heme synthesis blockade in cell systems.3,4 |
| 别名 | NMPP;N-methyl PPIX; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ortiz de Montellano, P.R.,Beilan, H.S. and Kunze, K.L. N-Methylprotoporphyrin IX: Chemical synthesis and identification as the green pigment produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine treatment. Proc. Natl. Acad. Sci. USA 78(3), 1490-1494 (1981). 2.Shi, Z. and Ferreira, G.C. Modulation of inhibition of ferrochelatase by N-methylprotoporphyrin. Biochem. J. 399(1), 21-28 (2006). 3.Atamna, H.,Brahmbhatt, M.,Atamna, W., et al. ApoHRP-based assay to measure intracellular regulatory heme. Metallomics 7(2), 309-321 (2015). 4.Lämsä, V.,Levonen, A.-L.,Sormunen, R., et al. Heme and heme biosynthesis intermediates induce heme oxygenase-1 and cytochrome P450 2A5, enzymes with putative sequential roles in heme and bilirubin metabolism: Different requirement for transcription factor nuclear factor erythroid- derived 2-like 2. Toxicol. Sci. 130(1), 132-144 (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% (a mixture of isomers) |
| 计算分子量 | 576.7 |
| 分子式 | C35H36N4O4 |
| CAS号 | 79236-56-9 |
| 稳定性 | ≥ 2 years |
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