| 货号 | 20385-1g |
| 描述 | Flunarizine is a calcium antagonist that acts as a potent dilator of peripheral vessels without having calcium-blocking actions in the heart.1 It reduces calcium fluxes in vascular smooth muscle by blocking both voltage-dependent calcium channels and receptor-operated channels.2 Flunarizine also acts as a dopamine D2 receptor antagonist.3 Through its action as a dilator of peripheral vessels, flunarizine has a role in the prophylaxis of migraine headaches.4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Singh, B.N. The mechanism of action of calcium antagonists relative to their clinical applications. Br. J. Clin. Pharmacol. 21, 109S-121S (1986). 2.Bian, K. and Toda, N. Vasodilator actions of flunarizine in isolated dog cerebral and extracerebral arteries. Jpn. J. Pharmacol. 49(1), 83-94 (1989). 3.Brücke, T.,Wöber, C.,Podreka, I., et al. D2 receptor blockade by flunarizine and cinnarizine explains extrapyramidal side effects. A SPECT study. J. Cereb. Blood Flow Metab. 15(3), 513-518 (1995). 4.Limmroth, V. and Michel, M.C. The prevention of migraine: A critical review with special emphasis on β-adrenoceptor blockers. Br. J. Clin. Pharmacol. 52(3), 237-243 (2001). 5.Pringsheim, T.,Davenport, W.J. and Becker, W.J. Prophylaxis of migraine headache. CMAJ 182(7), (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 477.4 |
| 分子式 | C26H26F2N2 • 2HCl |
| CAS号 | 30484-77-6 |
| 稳定性 | ≥ 2 years |
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