Entrectinib
货号：
19476-1mg 基本售价：
392.0 元 规格：
1 mg
产品信息
概述| 货号 | 19476-1mg |
| 描述 | Entrectinib is an inhibitor of TrkA (IC50 = 1.7 nM), TrkB (IC50 = 0.1 nM), and TrkC (IC50 = 0.1 nM), as well as C-ros oncogene 1 (ROS1; IC50 = 0.2 nM) and anaplastic lymphoma kinase (ALK; IC50 = 1.6 nM).1,2 Entrectinib blocks proliferation of ALK-dependent cell lines, including those with L1196M or C1156Y resistance mutations, and inhibits ALK‐dependent signaling.2,3 It has been shown to inhibit the growth of a non-small cell lung cancer cell line bearing an EML4-ALK rearrangement.2,3 In mice bearing various Trk, ROS1, or ALK-driven xenografts, entrectinib has been shown to induce tumor regression.2,3 |
| 别名 | NMS-E628;RXDX-101; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Siena, S.,Drilon, A.E.,Ou, S.H.I., et al. Enrectinib (RXDX-101), an oral pan-Trk, ROS1, and ALK inhibitor in patients with advanced solid tumors harboring gene rearrangements. (2015).
2.Ardini, E.,Menichincheri, M.,De Ponti, C., et al. Characterization of NMS-E628, a small molecule inhibitor of anaplastic lymphoma kinase with antitumor efficacy in ALK-dependent lymphoma and non-small cell lung cancer models. American Association for Cancer Research 8(12 suppl), (2009).
3.Sullivan, I. and Planchard, D. ALK inhibitors in non-small cell lung cancer: The latest evidence and developments. Ther.Adv.Med.Oncol. 8(1), 32-47 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 560.6 |
| 分子式 | C31H34F2N6O2 |
| CAS号 | 1108743-60-7 |
| 稳定性 | ≥ 2 years |
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