VR23
货号：
19133-1mg 基本售价：
392.0 元 规格：
1 mg
产品信息
概述| 货号 | 19133-1mg |
| 描述 | VR23 is a chloroquine (Item No. 14194) derivative that functions as a proteasome inhibitor (IC50s = 1 nM, 50-100 nM, and 3 µM for trypsin-like, chymotrypsin-like, and caspase-like proteasomes, respectively).1 It also deregulates the activity of cyclin E and other centrosomal proteins, resulting in the induction of multiple centrosome amplification, abnormal spindle formation, uneven cytokinesis, irreversible mitotic arrest, and eventually apoptosis that is specific to cancer cells.1 In combination with the chymotrypsin-like proteasome inhibitor bortezomib (Item No. 10008822), VR23 can produce a synergistic effect in killing multiple myeloma cells, including those that are resistant to bortezomib.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pundir, S.,Vu, H.Y.,Solomon, V.R., et al. VR23: A quinoline-sulfonyl hybrid proteasome inhibitor that selectively kills cancer via cyclin E-mediated centrosome amplification. Cancer Research 75(19), 4164-4175 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 477.9 |
| 分子式 | C19H16ClN5O6S |
| CAS号 | 1624602-30-7 |
| 稳定性 | ≥ 2 years |
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