Imidapril (hydrochloride)
货号：
18854-5mg 基本售价：
392.0 元 规格：
5 mg
产品信息
概述| 货号 | 18854-5mg |
| 描述 | Imidapril is a prodrug for the active metabolite imidaprilat, an angiotensin-converting enzyme inhibitor that suppresses the conversion of angiotensin I to angiotensin II (IC50 = 2.6 nM), thereby preventing vasoconstriction and decreasing aldosterone secretion by the adrenal cortex.1 In clinical trials, imidapril was effective at lowering plasma and tissue angiotensin II levels, resulting in peripheral vasodilation, reduced blood pressure, renoprotective effects in patients with type 1 diabetes, and decreased renal sodium and water retention.2,3 |
| 别名 | TA-6366; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kubo, M.,Kato, J.,Ochiai, T., et al. Pharmacological studies on (4S)-1-methyl-3-[(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino] propionyl]-2-oxo-imidazolidine-4-carboxylic acid hydrochloride (TA-6366), a new ACE inhibitor: I. ACE inhibitory and anti-hypertensive activities. Japanese Journal of Pharmacology 53(2), 201-210 (1990).
2.Robinson, D.M.,Curran, M.P. and Lyseng-Williamson, K.A. Imidapril: A review of its use in essential hypertension, type 1 diabetic nephropathy and chronic heart failure. Drugs 67(9), 1359-1378 (2007).
3.Hosoya, K. and Ishimitsu, T. Protection of the cardiovascular system by imidapril, a versatile angiotensin-converting enzyme inhibitor. Cardiovascular Drug Reviews 20(2), 93-110 (2002).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 441.9 |
| 分子式 | C20H27N3O6 • HCl |
| CAS号 | 89396-94-1 |
| 稳定性 | ≥ 2 years |
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