Cimetidine
货号：
18743-5g 基本售价：
392.0 元 规格：
5 g
产品信息
概述| 货号 | 18743-5g |
| 描述 | Histamine H2 receptors mediate gastric acid secretion by coupling to Gαs proteins and increasing cAMP formation.1 Cimetidine is an H2 receptor antagonist (Ki = 0.6 µM) that competitively inhibits the binding of histamine to H2 receptors, thereby reducing both intracellular cAMP concentrations and acid secretion by parietal cells.2,3 Inverse agonist activity of cimetidine has been described to account for its ability to upregulate histamine H2 receptors in CHO cells.4 |
| 别名 | NSC 335308;SKF 92334; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bakker, R.A.,Timmerman, H. and Leurs, R. Histamine receptors: Specific ligands, receptor biochemistry, and signal transduction. Clin.Allergy Immunol. 17, 27-64 (2002).
2.Feldman, M. and Burton, M.E. Histamine2-receptor antagonists. Standard therapy for acid-peptic diseases. (First of two parts). New England Journal of Medicine 323(24), 1672-1680 (1990).
3.Smit, M.J.,Leurs, R.,Alewijnse, A.E., et al. Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors. Proceedings of the National Academy of Sciences of the United States of America 93(13), 6802-6807 (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 252.3 |
| 分子式 | C10H16N6S |
| CAS号 | 51481-61-9 |
| 稳定性 | ≥ 2 years |
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