LDN-212854
货号：
17698-1mg 基本售价：
392.0 元 规格：
1 mg
产品信息
概述| 货号 | 17698-1mg |
| 描述 | Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. LDN-212854 inhibits ALK2 (IC50 = 1.3 nM) in preference to other BMP type I receptors, ALK1 (IC50 = 2.4 nM) and ALK3 (IC50 = 85.8 nM) and with over 1,500-fold selectivity against the closely related activin and TGF-β type I receptors (i.e., ALK4 and ALK5).1 It has been shown to inhibit BMP6-induced osteogenic differentiation, which functions predominantly via ALK2, with an IC50 value of 10 nM.1 LDN-212854 also demonstrates off-target activity against RIPK2, ABL1, and PDGFRβ kinases with IC50 values less than 100 nM.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mohedas, A.H.,Xing, X.,Armstrong, K.A., et al. Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chemical Biology 8(6), 1291-1302 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 406.5 |
| 分子式 | C25H22N6 |
| CAS号 | 1432597-26-6 |
| 稳定性 | ≥ 2 years |
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