| 货号 | 16882-1mg |
| 描述 | Clozapine (Item No. 12059) is an atypical anti-psychotic compound that modulates a range of neurological receptors.1,2 Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration.3 It is produced by the action of cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4, whose activities, in turn, can be affected by drugs and disease.4,5 Clozapine N-oxide is normally biologically inactive. However, it can be used in designer receptor exclusively activated by designer drug, also known as DREADD, technology to modulate synthetic receptors in vivo.6,7 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Richelson, E. and Souder, T. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sciences 68(1), 29-39 (2000). 2.Rummel-Kluge, C.,Komossa, K.,Schwarz, S., et al. Second-generation antipsychotic drugs and extrapyramidal side effects: A systematic review and meta-analysis of head-to-head comparisons. Schizophr.Bull. 38(1), 167-177 (2012). 3.Dain, J.G.,Nicoletti, J. and Ballard, F. Biotransformation of clozapine in humans. Drug Metabolism and Disposition 25(5), 603-609 (1997). 4.Eiermann, B.,Engel, G.,Johansson, I., et al. The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine. British Journal of Clinical Pharmacology 44(5), 439-446 (1997). 5.Zhang, W.V.,Ramzan, I. and Murray, M. Impaired microsomal oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis. Journal of Pharmacology and Experimental Therapeutics 322(2), 770-777 (2007). 6.Ray, R.S.,Corcoran, A.E.,Brust, R.D., et al. Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition. Science 333(6042), 637-642 (2012). 7.Kätzel, D.,Nocholson, E.,Schorge, S., et al. Chemical-genetic attenuation of focal neocortical seizures. Nat.Commun. 5, 1-9 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 342.8 |
| 分子式 | C18H19ClN4O |
| CAS号 | 34233-69-7 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |