| 货号 | 14176-1mg |
| 描述 | Idarubicin is a 4-demethoxy analog of the leukemia therapeutic daunorubicin (Item No. 14159). Both are anthracycline antibiotics which intercalate in DNA and inhibit topoisomerase II, resulting in cancer cell cytotoxicity at low concentrations (IC50 = 20-120 nM for idarubicin).1,2,3 Idarubicin is effective in combination therapy for the treatment of different types of leukemia.4,5 |
| 别名 | 4-Demethoxydaunorubicin;4-DMD;NSC 256439; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Arcamone, F. Properties of antitumor anthracyclines and new developments in their application: Cain memorial award lecture. Cancer Research 45, 5995-5999 (1985). 2.Dautant, A.,dEstaintot, B.L.,Gallois, B., et al. A trigonal form of the idarubicin:d(CGATCG) complex; crystal and molecular structure at 2.0 Å resolution. Nucleic Acids Research 23(10), 1710-1716 (1995). 3.Binaschi, M.,Farinosi, R.,Austin, C.A., et al. Human DNA topoisomerase IIα-dependent DNA cleavage and yeast cell killing by anthracycline analogues. Cancer Research 58, 1886-1892 (1998). 4.Tallman, M.S.,Gilliland, D.G. and Rowe, J.M. Drug therapy for acute myeloid leukemia. Blood 106(4), 1154-1163 (2005). 5.Wang, Z.Y. and Chen, Z. Acute promyelocytic leukemia: From highly fatal to highly curable. Blood 111(5), 2505-2515 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 534 |
| 分子式 | C26H27NO9 • HCl |
| CAS号 | 57852-57-0 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |