INCB 3284 (dimesylate)
货号：
11963-1mg 基本售价：
392.0 元 规格：
1 mg
产品信息
概述| 货号 | 11963-1mg |
| 描述 | CCR2 is the receptor for the chemokine CCL2, known commonly as monocyte chemotactic protein-1 (MCP-1). INCB 3284 is a potent, selective, and orally bioavailable antagonist of monocyte chemotactic protein-1 binding to CCR2 (IC50 = 3.7 nM).1 For comparison, it has no significant inhibitor action at over 50 ion channels, transporters, GPCRs, and other chemokine receptors when tested at a concentration of 1 μM.1 INCB 3284 inhibits chemotaxis in vitro(IC50 = 4.7 nM) and displays acceptable oral bioavailability in mice, rats, dogs, monkeys, and chimpanzees.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Xue, C.B.,Feng, H.,Cao, G., et al. Discovery of INCB3284, a potent, selective, and orally bioavailable hCCR2 antagonist. ACS Med.Chem.Lett. 2, 450-454 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 712.8 |
| 分子式 | C26H31F3N4O4 • 2CH3SO3H |
| CAS号 | 887401-93-6 |
| 稳定性 | ≥ 2 years |
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