| 货号 | 11727-50mg |
| 描述 | Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influence on target neurons. These receptors are the major targets for benzodiazepines and related anxiolytic drugs.1 Bicuculline is a competitive GABAA receptor antagonist that can act as an allosteric inhibitor at GABAAreceptors.2,3 At 100 μM, it blocks spontaneously opening chloride channels in the outside-out patches from the cultured cortical neurons.3 Bicuculline also reversibly blocks GABAA receptors on horizontal cells in the mouse retina with an IC50 value of 1.7 μM.4 By blocking the inhibitory action of GABA, bicuculline mimics the action of epilepsy and is widely used in experimental studies as a convulsant, inducing seizure in hippocampal or cortical neurons in prepared brain slices.5 |
| 别名 | NSC 32192; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Karobath, M., and Sperk, G. Stimulation of benzodiazepine receptor binding by γ-aminobutyric acid. Proceedings of the National Academy of Sciences of the United States of America 76(2), 1004-1006 (1979). 2.Ueno, S.,Bracamontes, J.,Zorumski, C., et al. Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor. Journal of Neuroscience 17(2), 625-634 (1997). 3.Birnir, B.,Eghbali, M.,Everitt, A.B., et al. Bicuculline, pentobarbital and diazepam modulate spontaneous GABAA channels in rat hippocampal neurons. British Journal of Pharmacology 131(4), 695-704 (2000). 4.Feigenspan, A., and Weiler, R. Electrophysiological properties of mouse horizontal cell GABAA receptors. Journal of Neurophysiology 92(5), 2789-2801 (2004). 5.Baram, T.Z., and Snead, O.C., III. Bicuculline induced seizures in infant rats: Ontogeny of behavioral and electrocortical phenomena. Brain Res.Dev.Brain Res. 57(2), 291-295 (1990). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 367.4 |
| 分子式 | C20H17NO6 |
| CAS号 | 485-49-4 |
| 稳定性 | ≥ 2 years |
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