Necrostatin-1
货号：
11658-5mg 基本售价：
392.0 元 规格：
5 mg
产品信息
概述| 货号 | 11658-5mg |
| 描述 | Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand–induced and tumor necrosis factor-α (TNF-α) induced necrosis.1 Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 490 nM.2,1 It has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction.2,1 |
| 别名 | Nec-1; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Teng, X.,Degterev, A.,Jagtap, P., et al. Structure-activity relationship study of novel necroptosis inhibitors. Bioorg. Med. Chem. Lett. 15(22), 5039-5044 (2005).
2.Degterev, A.,Hitomi, J.,Germscheid, M., et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nature Chemical Biology 4(5), 313-321 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 259.3 |
| 分子式 | C13H13N3OS |
| CAS号 | 4311-88-0 |
| 稳定性 | ≥ 2 years |
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