4-Quinolone-3-Carboxamide CB2 Ligand
货号：
11093-1mg 基本售价：
392.0 元 规格：
1 mg
产品信息
概述| 货号 | 11093-1mg |
| 描述 | Cannabinoids (CBs) and their synthetic analogs produce biochemical and pharmacological effects by interacting with the central CB1 and peripheral CB2 receptors. The CB2 receptor has emerged as a pharmacotherapeutic target for treating osteoporosis, as well as for eliciting antinociceptive effects in various models of pain. 4-Quinolone-3-carboxamide CB2 ligand is a selective, high-affinity ligand of the CB2 receptor, displaying a Ki value of 0.6 nM (Ki >10,000 nM for CB1)in vitro. At a dose of 6 mg/kg, 4-quinolone-3-carboxamide CB2 ligand exhibits antinociceptive activity in a formalin test of nocifensive response in mice. This analgesic affect is not significantly reversed by the CB2 antagonist AM630 (Item No. 10006974), which suggests 4-quinolone-3-carboxamide CB2 ligand may behave as an inverse agonist.1 |
| 别名 | 4Q3C CB2Ligand; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pasquini, S.,De Rosa, M.,Pedani, V., et al. Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice. Journal of Medicinal Chemistry 54, 5444-5453 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 422.6 |
| 分子式 | C26H34N2O3 |
| CAS号 | 1314230-69-7 |
| 稳定性 | ≥ 2 years |
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