coumarin-SAHA
货号：
10671-1mg 基本售价：
392.0 元 规格：
1 mg
产品信息
概述| 货号 | 10671-1mg |
| 描述 | Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access.1 coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino “cap” group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. 2 The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm, respectively and is quenched by 50% when bound to HDAC8.2 This probe can be used to determine binding affinities and dissociation off-rates of HDAC enzyme-inhibitor complexes and is well-suited for high-throughput screening. |
| 别名 | coumarin-Suberoylanilide Hydroxamic Acid; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Marks, P.A., and Breslow, R. Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug. Nat. Biotechnol. 25(1), 84-90 (2007).
2.Singh, R.K.,Mandal, T.,Balasubramanian, N., et al. Coumarin-suberoylanilide hydroxamic acid as a fluorescent probe for determining binding affinities and off-rates of histone deacetylase inhibitors. Analytical Biochemistry 408, 309-315 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 346.4 |
| 分子式 | C18H22N2O5 |
| CAS号 | 1260635-77-5 |
| 稳定性 | ≥ 2 years |
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