KT 5823
货号：
10010965-25ug 基本售价：
392.0 元 规格：
25 ug
产品信息
概述| 货号 | 10010965-25ug |
| 描述 | The activity of cGMP-dependent protein kinase (PKG) is controlled by factors that elevate cellular cGMP, like nitric oxide (NO), and by those that reduce cGMP levels, like certain phosphodiesterases. KT 5823 is a potent, selective inhibitor of cGMP-dependent protein kinase (PKG) (in vitroIC50 = 234 nM).1 KT 5823 is cell-permeable and is often used in intact cells to assess the role of PKG in signaling, although there are cases where it poorly inhibits PKG in cells.2 KT 5823 is a weak inhibitor of PKC (Ki = 4 µM) and PKA (Ki >10 µM).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hidaka, H., and Kobayashi, R. Pharmacology of protein kinase inhibitors. Annual Reviews of Pharmacology and Toxicology 32, 377-397 (1992).
2.Burkhardt, M.,Glazova, M.,Gambaryan, S., et al. KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells. The Journal of Biological Chemisty 275(43), 33536-33541 (2000).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 495.5 |
| 分子式 | C29H25N3O5 |
| CAS号 | 126643-37-6 |
| 稳定性 | ≥ 1 year |
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