| 货号 | 10008613-1mg |
| 描述 | Peroxisome proliferator-activated receptor-α (PPARα) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis.1,2 Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport.3 GW 7647 is a potent, selective agonist of human and murine PPARα4 It activates human PPARα, PPARγ, and PPARδ with EC50 values of 0.006, 1.1 and 6.2 µM, respectively, in a GAL4-PPAR binding assay. Similar EC50 values of 0.001, 1.3, and 2.9 were observed with the murine receptors. GW 7647 lowered triglycerides 93% and 60% in fat-fed hamsters and rats, respectively, at a dose of 3 mg/kg.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Latruffe, N., and Vamecq, J. Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism. Biochimie 79, 81-94 (1997). 2.Lemberger, T.,Desvergne, B., and Wahli, W. Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology. Annual Reviews of Cell Development and Biology 12, 335-363 (1996). 3.Mandard, S.,Müller, M., and Kersten, S. Peroxisome proliferator-activated receptor α target genes. Cellular and Molecular Life Sciences 61, 393-416 (2004). 4.Brown, P.J.,Stuart, L.W.,Hurley, K.P., et al. Identification of a subtype selective human PPARα agonist through parallel-array synthesis. Bioorganic & Medicinal Chemistry Letters 11, 1225-1227 (2001). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 502.8 |
| 分子式 | C29H46N2O3S |
| CAS号 | 265129-71-3 |
| 稳定性 | ≥ 2 years |
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